The Pneumonia Virus of Mice (PVM) model of acute respiratory infection.
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ABSTRACT:
SUBMITTER: Dyer KD
PROVIDER: S-EPMC3528276 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
The Pneumonia Virus of Mice (PVM) model of acute respiratory infection.
Dyer Kimberly D KD Garcia-Crespo Katia E KE Glineur Stephanie S Domachowske Joseph B JB Rosenberg Helene F HF
Viruses 20121201 12
Pneumonia Virus of Mice (PVM) is related to the human and bovine respiratory syncytial virus (RSV) pathogens, and has been used to study respiratory virus replication and the ensuing inflammatory response as a component of a natural host—pathogen relationship. As such, PVM infection in mice reproduces many of the clinical and pathologic features of the more severe forms of RSV infection in human infants. Here we review some of the most recent findings on the basic biology of PVM infection and it ...[more]
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