Use of the Syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers.
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ABSTRACT:
SUBMITTER: Wahl-Jensen V
PROVIDER: S-EPMC3528289 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
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Use of the Syrian hamster as a new model of ebola virus disease and other viral hemorrhagic fevers.
Wahl-Jensen Victoria V Bollinger Laura L Safronetz David D de Kok-Mercado Fabian F Scott Dana P DP Ebihara Hideki H
Viruses 20121214 12
Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research laboratory animal, as well as current benefits and challenges of this model. Availability of immunological reagents is addressed. Salient features of EVD in hamsters, including relev ...[more]
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