Ontology highlight
ABSTRACT:
SUBMITTER: Marek D
PROVIDER: S-EPMC3528457 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Marek Diana D Papin Stephanie S Ellefsen Kim K Niederhauser Julien J Isidor Nathalie N Ransijn Adriana A Poupon Lucienne L Spertini Francois F Pantaleo Giuseppe G Bergmann Sven S Beckmann Jacques S JS Jacquemont Sebastien S Tanackovic Goranka G
Journal of neuroinflammation 20121013
<h4>Background</h4>Fragile X-associated tremor/ataxia syndrome (FXTAS) is an inherited late-onset neurodegenerative disorder, characterized both by neurological and cognitive deficits. It is caused by the expansion of CGG repeats (55 to 200 repeats) in the noncoding region of the fragile X mental retardation 1 (FMR1) gene. Abnormal immunological patterns are often associated with neurodegenerative disorders and implicated in their etiology. We therefore investigated the immune status of FXTAS pa ...[more]