Ontology highlight
ABSTRACT:
SUBMITTER: Bursac S
PROVIDER: S-EPMC3528581 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Bursać Sladana S Brdovčak Maja Cokarić MC Pfannkuchen Martin M Orsolić Ines I Golomb Lior L Zhu Yan Y Katz Chen C Daftuar Lilyn L Grabušić Kristina K Vukelić Iva I Filić Vedrana V Oren Moshe M Prives Carol C Volarevic Siniša S
Proceedings of the National Academy of Sciences of the United States of America 20121120 50
Impairment of ribosomal biogenesis can activate the p53 protein independently of DNA damage. The ability of ribosomal proteins L5, L11, L23, L26, or S7 to bind Mdm2 and inhibit its ubiquitin ligase activity has been suggested as a critical step in p53 activation under these conditions. Here, we report that L5 and L11 are particularly important for this response. Whereas several other newly synthesized ribosomal proteins are degraded by proteasomes upon inhibition of Pol I activity by actinomycin ...[more]