Ontology highlight
ABSTRACT:
SUBMITTER: Simmer F
PROVIDER: S-EPMC3528691 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Simmer Femke F Brinkman Arie B AB Assenov Yassen Y Matarese Filomena F Kaan Anita A Sabatino Lina L Villanueva Alberto A Huertas Dori D Esteller Manel M Lengauer Thomas T Bock Christoph C Colantuoni Vittorio V Altucci Lucia L Stunnenberg Hendrik G HG
Epigenetics 20121018 12
Aberrant DNA methylation often occurs in colorectal cancer (CRC). In our study we applied a genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially methylated regions (DMRs) in 24 tumors and matched normal colon samples. In total, 2687 frequently hypermethylated and 468 frequently hypomethylated regions were identified, which include potential biomarkers for CRC diagnosis. Hypermethylation in the tumor samples was enriched at CpG islands and gene promoters, while ...[more]