Ontology highlight
ABSTRACT:
SUBMITTER: Rojas M
PROVIDER: S-EPMC3528734 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Rojas Marta M Farr George W GW Fernandez Cesar F CF Lauden Laura L McCormack John C JC Wolin Sandra L SL
PloS one 20121221 12
Although a CCTG expansion in the gene encoding the zinc knuckle protein CNBP causes a common form of muscular dystrophy, the function of both human CNBP and its putative budding yeast ortholog Gis2 remain poorly understood. Here we report the protein interactions of Gis2 and the subcellular locations of both Gis2 and CNBP. We found that Gis2 exhibits RNA-dependent interactions with two proteins involved in mRNA recognition, the poly(A) binding protein and the translation initiation factor eIF4G. ...[more]