Ontology highlight
ABSTRACT:
SUBMITTER: Baraniak PR
PROVIDER: S-EPMC3528787 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Baraniak Priya R PR Cooke Marissa T MT Saeed Rabbia R Kinney Melissa A MA Fridley Krista M KM McDevitt Todd C TC
Journal of the mechanical behavior of biomedical materials 20120303
Culturing multipotent adult mesenchymal stem cells as 3D aggregates augments their differentiation potential and paracrine activity. One caveat of stem cell spheroids, though, can be the limited diffusional transport barriers posed by the inherent 3D structure of the multicellular aggregates. In order to circumvent such limitations, polymeric microparticles have been incorporated into stem cell aggregates as a means to locally control the biochemical and physical properties of the 3D microenviro ...[more]