Ontology highlight
ABSTRACT:
SUBMITTER: Duncan GS
PROVIDER: S-EPMC3529073 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Duncan Gordon S GS Brenner Dirk D Tusche Michael W MW Brüstle Anne A Knobbe Christiane B CB Elia Andrew J AJ Mock Thomas T Bray Mark R MR Krammer Peter H PH Mak Tak W TW
Proceedings of the National Academy of Sciences of the United States of America 20121203 51
The endogenous metabolite of estradiol, 2-Methoxyestradiol (2ME2), is an antimitotic and antiangiogenic cancer drug candidate that also exhibits disease-modifying activity in animal models of rheumatoid arthritis (RA). We found that 2ME2 dramatically suppresses development of mouse experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple sclerosis (MS). 2ME2 inhibits in vitro lymphocyte activation, cytokine production, and proliferation in a dose-dependent fashion. 2ME2 treatm ...[more]