Ontology highlight
ABSTRACT:
SUBMITTER: Ma D
PROVIDER: S-EPMC3529077 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Ma Dongyuan D Wang Lu L Wang Sifeng S Gao Ya Y Wei Yonglong Y Liu Feng F
Proceedings of the National Academy of Sciences of the United States of America 20121203 51
The thymus is mainly comprised of thymic epithelial cells (TECs), which form the unique thymic epithelial microenvironment essential for intrathymic T-cell development. Foxn1, a member of the forkhead transcription factor family, is required for establishing a functional thymic rudiment. However, the molecular mechanisms underlying the function of Foxn1 are still largely unclear. Here, we show that Foxn1 functions in thymus development through Mcm2 in the zebrafish. We demonstrate that, in foxn1 ...[more]