Ontology highlight
ABSTRACT:
SUBMITTER: Irausquin SJ
PROVIDER: S-EPMC3529174 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Virus research 20091106 2
Analysis of complete polyprotein-encoding sequences of the two most prevalent genotypes of hepatitis C virus (HCV-1a and HCV-1b) revealed evidence of abundant, slightly deleterious nonsynonymous variants subject to ongoing purifying selection. In the case of both HCV-1a and HCV-1b, the NS3 protein demonstrated a high incidence of forward-and-backward or parallel nonsynonymous changes in CTL epitopes as measured by the phylogenetic consistency index. These results imply that certain nonsynonymous ...[more]