Ontology highlight
ABSTRACT:
SUBMITTER: Ngok SP
PROVIDER: S-EPMC3529520 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Ngok Siu P SP Geyer Rory R Liu Miaoliang M Kourtidis Antonis A Agrawal Sudesh S Wu Chuanshen C Seerapu Himabindu Reddy HR Lewis-Tuffin Laura J LJ Moodie Karen L KL Huveldt Deborah D Marx Ruth R Baraban Jay M JM Storz Peter P Horowitz Arie A Anastasiadis Panos Z PZ
The Journal of cell biology 20121217 7
Vascular endothelial growth factor (VEGF) and Ang1 (Angiopoietin-1) have opposing effects on vascular permeability, but the molecular basis of these effects is not fully known. We report in this paper that VEGF and Ang1 regulate endothelial cell (EC) junctions by determining the localization of the RhoA-specific guanine nucleotide exchange factor Syx. Syx was recruited to junctions by members of the Crumbs polarity complex and promoted junction integrity by activating Diaphanous. VEGF caused tra ...[more]