Ontology highlight
ABSTRACT:
SUBMITTER: Courilleau C
PROVIDER: S-EPMC3529529 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Courilleau Céline C Chailleux Catherine C Jauneau Alain A Grimal Fanny F Briois Sébastien S Boutet-Robinet Elisa E Boudsocq François F Trouche Didier D Canitrot Yvan Y
The Journal of cell biology 20121201 7
DNA damage signaling and repair take place in a chromatin context. Consequently, chromatin-modifying enzymes, including adenosine triphosphate-dependent chromatin remodeling enzymes, play an important role in the management of DNA double-strand breaks (DSBs). Here, we show that the p400 ATPase is required for DNA repair by homologous recombination (HR). Indeed, although p400 is not required for DNA damage signaling, DNA DSB repair is defective in the absence of p400. We demonstrate that p400 is ...[more]