Ontology highlight
ABSTRACT:
SUBMITTER: Vernochet C
PROVIDER: S-EPMC3529641 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Vernochet Cecile C Mourier Arnaud A Bezy Olivier O Macotela Yazmin Y Boucher Jeremie J Rardin Matthew J MJ An Ding D Lee Kevin Y KY Ilkayeva Olga R OR Zingaretti Cristina M CM Emanuelli Brice B Smyth Graham G Cinti Saverio S Newgard Christopher B CB Gibson Bradford W BW Larsson Nils-Göran NG Kahn C Ronald CR
Cell metabolism 20121115 6
Obesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, but the role for adipose tissue mitochondria in the development of these disorders is currently unknown. To understand the impact of adipose tissue mitochondria on whole-body metabolism, we have generated a mouse model with disruption of the mitochondrial transcription factor A (TFAM) specifically in fat. F-TFKO adipose tissue exhibit decreased mtDNA copy number, altered levels of proteins of the electro ...[more]