Ontology highlight
ABSTRACT:
SUBMITTER: Pos W
PROVIDER: S-EPMC3530167 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Pos Wouter W Sethi Dhruv K DK Call Melissa J MJ Schulze Monika-Sarah E D MS Anders Anne-Kathrin AK Pyrdol Jason J Wucherpfennig Kai W KW
Cell 20121201 7
HLA-DR molecules bind microbial peptides in an endosomal compartment and present them on the cell surface for CD4 T cell surveillance. HLA-DM plays a critical role in the endosomal peptide selection process. The structure of the HLA-DM-HLA-DR complex shows major rearrangements of the HLA-DR peptide-binding groove. Flipping of a tryptophan away from the HLA-DR1 P1 pocket enables major conformational changes that position hydrophobic HLA-DR residues into the P1 pocket. These conformational changes ...[more]