The role of the Panton-Valentine leucocidin toxin in staphylococcal disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Invasive community-onset staphylococcal disease has emerged worldwide associated with Panton-Valentine leucocidin (PVL) toxin. Whether PVL is pathogenic or an epidemiological marker is unclear. We investigate the role of PVL in disease, colonisation, and clinical outcome.

Methods

We searched Medline and Embase for original research reporting the prevalence of PVL genes among Staphylococcus aureus pneumonia, bacteraemia, musculoskeletal infection, skin and soft-tissue infection, or colonisation published before Oct 1, 2011. We calculated odds ratios (ORs) to compare patients with PVL-positive colonisation and each infection relative to the odds of PVL-positive skin and soft-tissue infection. We did meta-analyses to estimate odds of infection or colonisation with a

SUBMITTER: Shallcross LJ 

PROVIDER: S-EPMC3530297 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature