Ontology highlight
ABSTRACT:
SUBMITTER: Begg CB
PROVIDER: S-EPMC3530356 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Begg Colin B CB Zabor Emily C EC
American journal of epidemiology 20120824 6
Contemporary searches for new risk factors frequently involve genome-wide explorations of very large numbers of candidate risk variants. Given that diseases can often be classified into subtypes that possess evidence of etiologic heterogeneity, the question arises as to whether or not a search for new risk factors would be improved by looking separately within subtypes. Etiologic risk heterogeneity inevitably increases the signal in at least one of the subtypes, but this advantage may be offset ...[more]