Ontology highlight
ABSTRACT:
SUBMITTER: Almlof JC
PROVIDER: S-EPMC3530574 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Almlöf Jonas Carlsson JC Lundmark Per P Lundmark Anders A Ge Bing B Maouche Seraya S Göring Harald H H HH Liljedahl Ulrika U Enström Camilla C Brocheton Jessy J Proust Carole C Godefroy Tiphaine T Sambrook Jennifer G JG Jolley Jennifer J Crisp-Hihn Abigail A Foad Nicola N Lloyd-Jones Heather H Stephens Jonathan J Gwilliam Rhian R Rice Catherine M CM Hengstenberg Christian C Samani Nilesh J NJ Erdmann Jeanette J Schunkert Heribert H Pastinen Tomi T Deloukas Panos P Goodall Alison H AH Ouwehand Willem H WH Cambien François F Syvänen Ann-Christine AC
PloS one 20121226 12
A large number of genome-wide association studies have been performed during the past five years to identify associations between SNPs and human complex diseases and traits. The assignment of a functional role for the identified disease-associated SNP is not straight-forward. Genome-wide expression quantitative trait locus (eQTL) analysis is frequently used as the initial step to define a function while allele-specific gene expression (ASE) analysis has not yet gained a wide-spread use in diseas ...[more]