Ontology highlight
ABSTRACT:
SUBMITTER: Birsoy K
PROVIDER: S-EPMC3530647 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Birsoy Kivanç K Wang Tim T Possemato Richard R Yilmaz Omer H OH Koch Catherine E CE Chen Walter W WW Hutchins Amanda W AW Gultekin Yetis Y Peterson Tim R TR Carette Jan E JE Brummelkamp Thijn R TR Clish Clary B CB Sabatini David M DM
Nature genetics 20121202 1
There is increasing evidence that oncogenic transformation modifies the metabolic program of cells. A common alteration is the upregulation of glycolysis, and efforts to target glycolytic enzymes for anticancer therapy are under way. Here, we performed a genome-wide haploid genetic screen to identify resistance mechanisms to 3-bromopyruvate (3-BrPA), a drug candidate that inhibits glycolysis in a poorly understood fashion. We identified the SLC16A1 gene product, MCT1, as the main determinant of ...[more]