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Rfam 11.0: 10 years of RNA families.

ABSTRACT: The Rfam database (available via the website at http://rfam.sanger.ac.uk and through our mirror at http://rfam.janelia.org) is a collection of non-coding RNA families, primarily RNAs with a conserved RNA secondary structure, including both RNA genes and mRNA cis-regulatory elements. Each family is represented by a multiple sequence alignment, predicted secondary structure and covariance model. Here we discuss updates to the database in the latest release, Rfam 11.0, including the introduction of genome-based alignments for large families, the introduction of the Rfam Biomart as well as other user interface improvements. Rfam is available under the Creative Commons Zero license.

SUBMITTER: Burge SW

PROVIDER: S-EPMC3531072 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Rfam 11.0: 10 years of RNA families.

Burge Sarah W SW Daub Jennifer J Eberhardt Ruth R Tate John J Barquist Lars L Nawrocki Eric P EP Eddy Sean R SR Gardner Paul P PP Bateman Alex A

Nucleic acids research 20121103 Database issue

The Rfam database (available via the website at http://rfam.sanger.ac.uk and through our mirror at http://rfam.janelia.org) is a collection of non-coding RNA families, primarily RNAs with a conserved RNA secondary structure, including both RNA genes and mRNA cis-regulatory elements. Each family is represented by a multiple sequence alignment, predicted secondary structure and covariance model. Here we discuss updates to the database in the latest release, Rfam 11.0, including the introduction of ...[more]

PMID: 23125362

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