Ontology highlight
ABSTRACT:
SUBMITTER: Pireddu R
PROVIDER: S-EPMC3531244 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
MedChemComm 20120127 6
Potent ROCK inhibitors of a new class of 1-benzyl-3-(4-pyridylthiazol-2-yl)ureas have been identified. Remarkable differences in activity were observed for ureas bearing a benzylic stereogenic center. Derivatives with hydroxy, methoxy and amino groups at the meta position of the phenyl ring give rise to the most potent inhibitors (low nM). Substitutions at the para position result in substantial loss of potency. Changes at the benzylic position are tolerated resulting in significant potency in t ...[more]