Dataset Information

Increased risk of acute pancreatitis in patients with type 2 diabetes: an observational study using a Japanese hospital database.

ABSTRACT:

Background

Increased risks of acute pancreatitis in patients with type 2 diabetes mellitus have been reported recently in several countries. We aimed to estimate the risks of acute pancreatitis in Japanese patients with diabetes mellitus.

Methods/findings

We examined a large-scale hospital administrative database consisting of one million patients in 16 secondary medical care hospitals, from 2003 to 2010. The incidence rates of acute pancreatitis were estimated with cohort design; the odds ratios associated with diabetes mellitus and other comorbid risk factors were estimated with separate case-control analyses. In cohort analysis, the incidence of acute pancreatitis was higher in 14,707 diabetic patients than in 186,032 non-diabetic patients (4.75 vs. 1.65 per 1,000 patient-years) and increased in male patients and as age advanced. The adjusted odds ratio of acute pancreatitis in patients with diabetes mellitus was 1.86 (P<0.001) compared with non-diabetic patients in case-control analysis from 1,372 cases and 5,469 matched controls, which is consistent with the ones reported in previous studies. Alcoholism and gallstones were associated with a large increase in the risk of acute pancreatitis (adjusted odds ratio 13.40 and 14.29, respectively, P<0.001), although dyslipidemia was associated with significant risk reduction (adjusted odds ratio 0.62, P<0.001).

Conclusions

This observational study ascertained the elevated incidence rates and risk of acute pancreatitis in Japanese patients with diabetes. The risk estimates in Japanese patients with diabetes were in agreement with the ones reported in previous studies, and the elevated risk of acute pancreatitis in patients with diabetes would be generalized in different locations/populations.

SUBMITTER: Urushihara H

PROVIDER: S-EPMC3531339 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Publications

Increased risk of acute pancreatitis in patients with type 2 diabetes: an observational study using a Japanese hospital database.

Urushihara Hisashi H Taketsuna Masanori M Liu Ying Y Oda Eisei E Nakamura Masaki M Nishiuma Shinichi S Maeda Rei R

PloS one 20121227 12

<h4>Background</h4>Increased risks of acute pancreatitis in patients with type 2 diabetes mellitus have been reported recently in several countries. We aimed to estimate the risks of acute pancreatitis in Japanese patients with diabetes mellitus.<h4>Methods/findings</h4>We examined a large-scale hospital administrative database consisting of one million patients in 16 secondary medical care hospitals, from 2003 to 2010. The incidence rates of acute pancreatitis were estimated with cohort design; ...[more]

PMID: 23300896

Similar Datasets

Project description:ObjectiveTo develop and validate a prediction model for predicting in-hospital mortality in patients with acute pancreatitis (AP).DesignA retrospective observational cohort study based on a large multicentre critical care database.SettingAll subject data were collected from the eICU Collaborative Research Database (eICU-CRD), which covers 200 859 intensive care unit admissions of 139 367 patients in 208 US hospitals between 2014 and 2015.ParticipantsA total of 746 patients with AP were drawn from eICU-CRD. Due to loss to follow-up (four patients) or incomplete data (364 patients), 378 patients were enrolled in the primary cohort to establish a nomogram model and to conduct internal validation.Primary and secondary outcome measuresThe outcome of the prediction model was in-hospital mortality. All risk factors found significant in the univariate analysis were considered for multivariate analysis to adjust for confounding factors. Then a nomogram model was established. The performance of the nomogram model was evaluated by the concordance index (C-index) and the calibration plot. The nomogram model was internally validated using the bootstrap resampling method. The predictive accuracy of the nomogram model was compared with that of Acute Physiology, Age, and Chronic Health Evaluation (APACHE) IV. Decision curve analysis (DCA) was performed to evaluate and compare the potential net benefit using of different predictive models.ResultsThe overall in-hospital mortality rate is 4.447%. Age, BUN (blood urea nitrogen) and lactate (ABL) were the independent risk factors determined by multivariate analysis. The C-index of nomogram model ABL (0.896 (95% CI 0.825 to 0.967)) was similar to that of APACHE IV (p=0.086), showing a comparable discriminating power. Calibration plot demonstrated good agreement between the predicted and the actual in-hospital mortality. DCA showed that the nomogram model ABL was clinically useful.ConclusionsNomogram model ABL, which used readily available data, exhibited high predictive value for predicting in-hospital mortality in AP.

Dataset Information

Increased risk of acute pancreatitis in patients with type 2 diabetes: an observational study using a Japanese hospital database.

Background

Methods/findings

Conclusions

Publications

Increased risk of acute pancreatitis in patients with type 2 diabetes: an observational study using a Japanese hospital database.

Similar Datasets

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