Ontology highlight
ABSTRACT:
SUBMITTER: Almeida AR
PROVIDER: S-EPMC3531415 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Almeida Afonso Rocha Martins AR Arroz-Madeira Sílvia S Fonseca-Pereira Diogo D Ribeiro Hélder H Lasrado Reena R Pachnis Vassilis V Veiga-Fernandes Henrique H
PloS one 20121227 12
Identification of thymocyte regulators is a central issue in T cell biology. Interestingly, growing evidence indicates that common key molecules control neuronal and immune cell functions. The neurotrophic factor receptor RET mediates critical functions in foetal hematopoietic subsets, thus raising the possibility that RET-related molecules may also control T cell development. We show that Ret, Gfra1 and Gfra2 are abundantly expressed by foetal and adult immature DN thymocytes. Despite the devel ...[more]