Ontology highlight
ABSTRACT:
SUBMITTER: Hershko K
PROVIDER: S-EPMC3531750 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Hershko Klilah K Simhadri Vijaya L VL Blaisdell Adam A Hunt Ryan C RC Newell Jordan J Tseng Sandra C SC Hershko Alon Y AY Choi Jae Won JW Sauna Zuben E ZE Wu Andrew A Bram Richard J RJ Komar Anton A AA Kimchi-Sarfaty Chava C
The Journal of biological chemistry 20121109 53
The protease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat) cleaves multimers of von Willebrand factor, thus regulating platelet aggregation. ADAMTS13 deficiency leads to the fatal disorder thrombotic thrombocytopenic purpura (TTP). It has been observed that cyclosporin A (CsA) treatment, particularly in transplant patients, may sometimes be linked to the development of TTP. Until now, the reason for such a link was unclear. Here we provide evidence demonstrating ...[more]