Ontology highlight
ABSTRACT:
SUBMITTER: Elantak L
PROVIDER: S-EPMC3531785 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Elantak Latifa L Espeli Marion M Boned Annie A Bornet Olivier O Bonzi Jeremy J Gauthier Laurent L Feracci Mikael M Roche Philippe P Guerlesquin Françoise F Schiff Claudine C
The Journal of biological chemistry 20121102 53
During B cell differentiation in the bone marrow, the expression and activation of the pre-B cell receptor (pre-BCR) constitute crucial checkpoints for B cell development. Both constitutive and ligand-dependent pre-BCR activation modes have been described. The pre-BCR constitutes an immunoglobulin heavy chain (Igμ) and a surrogate light chain composed of the invariant λ5 and VpreB proteins. We previously showed that galectin-1 (GAL1), produced by bone marrow stromal cells, is a pre-BCR ligand th ...[more]