Ontology highlight
ABSTRACT:
SUBMITTER: Straub AC
PROVIDER: S-EPMC3531883 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Straub Adam C AC Lohman Alexander W AW Billaud Marie M Johnstone Scott R SR Dwyer Scott T ST Lee Monica Y MY Bortz Pamela Schoppee PS Best Angela K AK Columbus Linda L Gaston Benjamin B Isakson Brant E BE
Nature 20121031 7424
Models of unregulated nitric oxide (NO) diffusion do not consistently account for the biochemistry of NO synthase (NOS)-dependent signalling in many cell systems. For example, endothelial NOS controls blood pressure, blood flow and oxygen delivery through its effect on vascular smooth muscle tone, but the regulation of these processes is not adequately explained by simple NO diffusion from endothelium to smooth muscle. Here we report a new model for the regulation of NO signalling by demonstrati ...[more]