Modelling reveals novel roles of two parallel signalling pathways and homeostatic feedbacks in yeast.
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ABSTRACT:
SUBMITTER: Schaber J
PROVIDER: S-EPMC3531907 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
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Modelling reveals novel roles of two parallel signalling pathways and homeostatic feedbacks in yeast.
Schaber Jörg J Baltanas Rodrigo R Bush Alan A Klipp Edda E Colman-Lerner Alejandro A
Molecular systems biology 20120101
The high osmolarity glycerol (HOG) pathway in yeast serves as a prototype signalling system for eukaryotes. We used an unprecedented amount of data to parameterise 192 models capturing different hypotheses about molecular mechanisms underlying osmo-adaptation and selected a best approximating model. This model implied novel mechanisms regulating osmo-adaptation in yeast. The model suggested that (i) the main mechanism for osmo-adaptation is a fast and transient non-transcriptional Hog1-mediated ...[more]
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