Ontology highlight
ABSTRACT:
SUBMITTER: Upton JW
PROVIDER: S-EPMC3531981 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Upton Jason W JW Kaiser William J WJ Mocarski Edward S ES
Cell host & microbe 20120301 3
Programmed necrosis, like apoptosis, eliminates pathogen-infected cells as a component of host defense. Receptor-interacting protein kinase (RIP) 3 (also called RIPK3) mediates RIP homotypic interaction motif (RHIM)-dependent programmed necrosis induced by murine cytomegalovirus (MCMV) infection or death receptor activation and suppressed by the MCMV-encoded viral inhibitor of RIP activation (vIRA). We find that interferon-independent expression of DNA-dependent activator of interferon regulator ...[more]