Dataset Information

Prognostic significance of progesterone receptor-positive tumor cells within immunohistochemically defined luminal A breast cancer.

ABSTRACT:

Purpose

Current immunohistochemical (IHC)-based definitions of luminal A and B breast cancers are imperfect when compared with multigene expression-based assays. In this study, we sought to improve the IHC subtyping by examining the pathologic and gene expression characteristics of genomically defined luminal A and B subtypes.

Patients and methods

Gene expression and pathologic features were collected from primary tumors across five independent cohorts: British Columbia Cancer Agency (BCCA) tamoxifen-treated only, Grupo Español de Investigación en Cáncer de Mama 9906 trial, BCCA no systemic treatment cohort, PAM50 microarray training data set, and a combined publicly available microarray data set. Optimal cutoffs of percentage of progesterone receptor (PR) -positive tumor cells to predict survival were derived and independently tested. Multivariable Cox models were used to test the prognostic significance.

Results

Clinicopathologic comparisons among luminal A and B subtypes consistently identified higher rates of PR positivity, human epidermal growth factor receptor 2 (HER2) negativity, and histologic grade 1 in luminal A tumors. Quantitative PR gene and protein expression were also found to be significantly higher in luminal A tumors. An empiric cutoff of more than 20% of PR-positive tumor cells was statistically chosen and proved significant for predicting survival differences within IHC-defined luminal A tumors independently of endocrine therapy administration. Finally, no additional prognostic value within hormonal receptor (HR) -positive/HER2-negative disease was observed with the use of the IHC4 score when intrinsic IHC-based subtypes were used that included the more than 20% PR-positive tumor cells and vice versa.

Conclusion

Semiquantitative IHC expression of PR adds prognostic value within the current IHC-based luminal A definition by improving the identification of good outcome breast cancers. The new proposed IHC-based definition of luminal A tumors is HR positive/HER2 negative/Ki-67 less than 14%, and PR more than 20%.

SUBMITTER: Prat A

PROVIDER: S-EPMC3532392 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Publications

Prognostic significance of progesterone receptor-positive tumor cells within immunohistochemically defined luminal A breast cancer.

Prat Aleix A Cheang Maggie Chon U MC Martín Miguel M Parker Joel S JS Carrasco Eva E Caballero Rosalía R Tyldesley Scott S Gelmon Karen K Bernard Philip S PS Nielsen Torsten O TO Perou Charles M CM

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20121210 2

<h4>Purpose</h4>Current immunohistochemical (IHC)-based definitions of luminal A and B breast cancers are imperfect when compared with multigene expression-based assays. In this study, we sought to improve the IHC subtyping by examining the pathologic and gene expression characteristics of genomically defined luminal A and B subtypes.<h4>Patients and methods</h4>Gene expression and pathologic features were collected from primary tumors across five independent cohorts: British Columbia Cancer Age ...[more]

PMID: 23233704

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Dataset Information

Prognostic significance of progesterone receptor-positive tumor cells within immunohistochemically defined luminal A breast cancer.

Purpose

Patients and methods

Results

Conclusion

Publications

Prognostic significance of progesterone receptor-positive tumor cells within immunohistochemically defined luminal A breast cancer.

Similar Datasets

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