Ontology highlight
ABSTRACT:
SUBMITTER: Tran V
PROVIDER: S-EPMC3532436 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Tran Vuong V Lim Cindy C Xie Jing J Chen Xin X
Science (New York, N.Y.) 20121101 6107
Stem cells can self-renew and generate differentiating daughter cells. It is not known whether these cells maintain their epigenetic information during asymmetric division. Using a dual-color method to differentially label "old" versus "new" histones in Drosophila male germline stem cells (GSCs), we show that preexisting canonical H3, but not variant H3.3, histones are selectively segregated to the GSC, whereas newly synthesized histones incorporated during DNA replication are enriched in the di ...[more]