Ontology highlight
ABSTRACT:
SUBMITTER: Castellino FJ
PROVIDER: S-EPMC3532496 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Castellino Francis J FJ Liang Zhong Z Davis Patrick K PK Balsara Rashna D RD Musunuru Harsha H Donahue Deborah L DL Smith Denise L DL Sandoval-Cooper Mayra J MJ Ploplis Victoria A VA Walsh Mark M
PloS one 20121228 12
To delineate the critical features of platelets required for formation and stability of thrombi, thromboelastography and platelet aggregation measurements were employed on whole blood of normal patients and of those with Bernard-Soulier Syndrome (BSS) and Glanzmann's Thrombasthenia (GT). We found that separation of platelet activation, as assessed by platelet aggregation, from that needed to form viscoelastic stable whole blood thrombi, occurred. In normal human blood, ristocetin and collagen ag ...[more]