Ontology highlight
ABSTRACT:
SUBMITTER: Wasilewski S
PROVIDER: S-EPMC3532595 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Wasilewski Sebastian S Calder Lesley J LJ Grant Tim T Rosenthal Peter B PB
Vaccine 20121010 51
We use electron cryotomography to reconstruct virions of two influenza A H3N2 virus strains. The maps reveal the structure of the viral envelope containing hemagglutinin (HA) and neuraminidase (NA) glycoproteins and the virus interior containing a matrix layer and an assembly of ribonucleoprotein particles (RNPs) that package the genome. We build a structural model for the viral surface by locating copies of the X-ray structure of the HA ectodomain into density peaks on the virus surface. We cal ...[more]