Dataset Information

Does cheese intake blunt the association between soft drink intake and risk of the metabolic syndrome? Results from the cross-sectional Oslo Health Study.

ABSTRACT:

Objectives

A high soft drink intake may promote, whereas intake of cheese may reduce risk of the metabolic syndrome (MetS), but will cheese intake blunt the soft drink versus MetS association?

Design

Cross-sectional study.

Setting

The Oslo Health Study.

Participants

Among the 18 770 participants of the Oslo Health Study there were 5344 men and 6150 women having data on cheese and soft drink intake and on risk factors for MetS, except for fasting glucose. The MetSRisk index=the weighted sum of triglycerides (TG), systolic blood pressure, diastolic blood pressure, waist circumference and body mass index (BMI) divided by high-density lipoprotein (HDL) were used as a combined risk estimate to examine the cheese/soft drink versus MetS interaction, and the SumRisk index was used to assess whether increasing intake of soft drinks/cheese would include an increasing number of MetS factors being above the cut-off values. We analysed the data using non-parametric correlation and analysis of covariance (ANCOVA).

Results

In all three groups of soft drink intake (seldom/rarely, 1-6 glasses/week, ≥1 glass/day), there was a negative cheese versus MetSRisk correlation (p≤0.003), but in the highest intake group the influence of cheese seemed to level off, suggesting interaction. However, there was no interaction between cheese and soft drinks within the fully adjusted models. Conversely, at all four levels of cheese intake, MetSRisk increased with an increasing intake of soft drinks (p≤0.001 at all cheese levels). Similar associations were found with the SumRisk index. When controlling for a large number of covariates (eg, sex, age group, smoking, education, physical activity, intake of fruits/berries and vegetables), the above associations prevailed.

Conclusions

Cheese intake blunted the association between soft drink intake and MetS, an influence possibly related to fatty acid desaturation, or to undetected covariates.

SUBMITTER: Hostmark AT

PROVIDER: S-EPMC3532972 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:BackgroundA few prospective studies have investigated the potential association of soft drink and non-caloric soft drink intake with high blood pressure using methods that adequately consider changes in intake over time and hypertensive status at baseline.ObjectiveTo prospectively examine the association of soft drink and non-caloric soft drink intake with systolic and diastolic blood pressure in a sample of Mexican adults, overall and by hypertension status.MethodsWe used data from the Health Workers Cohort Study spanning from 2004 to 2018 (n = 1,324 adults). Soft drink and non-caloric soft drink intake were assessed with a semiquantitative food frequency questionnaire. We fit multivariable-adjusted fixed-effects models to test the association of soft drink and non-caloric soft drink intake with systolic and diastolic blood pressure. The models were adjusted for potential confounders and considering the potential modifying effect of hypertension status at baseline.ResultsA one-serving increase in soft drink intake was associated with a 2.08 mm Hg (95% CI: 0.21, 3.94) increase in systolic blood pressure and 2.09 mm Hg (95% CI: 0.81, 3.36) increase in diastolic blood pressure over ten years. A stronger association between soft drink intake and diastolic pressure was observed among participants with versus without hypertension at baseline. We found no association between non-caloric soft drink intake and blood pressure.ConclusionsOur findings support the hypothesis that soft drink intake increases blood pressure. While further studies should be conducted to confirm our findings, food policies and recommendations to limit soft drink intake are likely to help reduce blood pressure at the population level. We probably did not find an association between non-caloric soft drink intake and blood pressure because of the low consumption of this type of beverage in the cohort. More studies will be needed to understand the potential effect of non-caloric beverages on blood pressure.