Dataset Information

Mansonella ozzardi corneal lesions in the Amazon: a cross-sectional study.

ABSTRACT: To characterise and confirm the presence of Mansonella ozzardi microfilariae in the cornea by biomicroscopy and corneal confocal microscopy.Cross-sectional study.Clinical practice study in patients from rural communities in Coari city on the Solimões river, Amazonas state, Brazil.The eyes of 212 consecutive volunteer patients were examined using a flash light and their blood checked for the presence of microfilariae by an expert microscopist. Patients with suspicious corneal lesions (characterised as nummular keratitis) were submitted to biomicroscopy, fundoscopy and corneal confocal microscopy evaluation (CCME). In two patients, a biopsy of the limbal conjunctiva adjacent to the nummular keratitis was carried out and blood collected from the surgical wound for microfilariae investigation by thick blood film examination.Positive correlation between corneal biomicroscopic and confocal lesions and M ozzardi microfilaremia.Of the 212 patients, 56 (26.4%) were positive for microfilaremia. 22 patients with nummular keratitis identified under flash light examination underwent biomicroscopy and CCME. Corneal lesions were positively correlated to microfilaremia (p=0.0001). At biomicroscopy, lesions were classified as quiescent or active. At CCME, lesions were categorised as circular or filiform. The associations between corneal lesions, CCME findings and microfilaremia are shown.We describe M ozzardi microfilariae in the cornea and the associated eye pathology. Further studies using ocular tissue PCR and other imaging techniques would be helpful.

SUBMITTER: Vianna LM

PROVIDER: S-EPMC3533123 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Mansonella ozzardi corneal lesions in the Amazon: a cross-sectional study.

Vianna Lucas Monferrari Monteiro LM Martins Marilaine M Cohen Marcos Jacob MJ Cohen Jacob Moyses JM Belfort Rubens R

BMJ open 20121127 6

<h4>Objectives</h4>To characterise and confirm the presence of Mansonella ozzardi microfilariae in the cornea by biomicroscopy and corneal confocal microscopy.<h4>Design</h4>Cross-sectional study.<h4>Settings</h4>Clinical practice study in patients from rural communities in Coari city on the Solimões river, Amazonas state, Brazil.<h4>Participants</h4>The eyes of 212 consecutive volunteer patients were examined using a flash light and their blood checked for the presence of microfilariae by an ex ...[more]

PMID: 23187969

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Project description:To analyze perceptions of health-related quality of life and associated factors in populations from the Manaus Metropolitan Region.We conducted a population-based cross-sectional study from May to August 2015. Adults aged 18 years and older were selected using probabilistic three-phase cluster sampling and stratified by sex and age, based on official estimates. Quality of life data were collected using the European Quality of Life 5-Dimensions 3-Levels (EQ-5D-3L) along with socioeconomic, demographic, and health perception data. Utility scores were calculated using the Brazilian version of the EQ-5D-3L. Descriptive statistics were derived, and a multivariate Tobit regression model with correction for complex sampling was performed to identify the variables that influence utility levels.A total of 4001 participants were included. The average utility score was 0.886 (95% confidence interval [CI]: 0.881-0.890) with significant differences according to living area (the capital (0.882 ± 0.144) or inner cities (0.908 ± 0.122; p < 0.001)). The dimension for which the highest proportion of people reported moderate to severe problems was pain/discomfort (39%), followed by anxiety/depression (18%). Men had a higher quality of life than women (β = 0.041, p < 0.001). Not working was a factor that increased quality of life compared with being formally employed (β = 0.031, p = 0.037). The poorest people had a lower quality of life than the richest people (β = -0.118, p < 0.001). Better health perceptions increased utility scores (p < 0.001), while being separated decreased the scores (β = -0.052, p = 0.001).Health-related quality of life in the Manaus Metropolitan Region was high, as expected for the general population, and was higher among individuals who lived in the inner cities, men and those in higher social classes. Gender discrepancies and differences in quality of life between the capital and inner cities should be further investigated.

Dataset Information

Mansonella ozzardi corneal lesions in the Amazon: a cross-sectional study.

Publications

Mansonella ozzardi corneal lesions in the Amazon: a cross-sectional study.

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