Myocardial ischemia-reperfusion injury: a neglected therapeutic target.
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ABSTRACT:
SUBMITTER: Hausenloy DJ
PROVIDER: S-EPMC3533275 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
Myocardial ischemia-reperfusion injury: a neglected therapeutic target.
Hausenloy Derek J DJ Yellon Derek M DM
The Journal of clinical investigation 20130102 1
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using either thombolytic therapy or primary percutaneous coronary intervention (PPCI). However, the process of reperfusion can itself induce cardiomyocyte death, known as myocardial reperfusion injury, for which there is still no effective therapy. A numbe ...[more]
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