Ontology highlight
ABSTRACT:
SUBMITTER: Almeida M
PROVIDER: S-EPMC3533305 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Almeida Maria M Iyer Srividhya S Martin-Millan Marta M Bartell Shoshana M SM Han Li L Ambrogini Elena E Onal Melda M Xiong Jinhu J Weinstein Robert S RS Jilka Robert L RL O'Brien Charles A CA Manolagas Stavros C SC
The Journal of clinical investigation 20121210 1
The detection of estrogen receptor-α (ERα) in osteoblasts and osteoclasts over 20 years ago suggested that direct effects of estrogens on both of these cell types are responsible for their beneficial effects on the skeleton, but the role of ERα in osteoblast lineage cells has remained elusive. In addition, estrogen activation of ERα in osteoclasts can only account for the protective effect of estrogens on the cancellous, but not the cortical, bone compartment that represents 80% of the entire sk ...[more]