Ontology highlight
ABSTRACT:
SUBMITTER: Holland AM
PROVIDER: S-EPMC3533530 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Holland Amanda M AM Zakrzewski Johannes L JL Tsai Jennifer J JJ Hanash Alan M AM Dudakov Jarrod A JA Smith Odette M OM West Mallory L ML Singer Natalie V NV Brill Jessie J Sun Joseph C JC van den Brink Marcel R M MR
The Journal of clinical investigation 20121119 12
Restoring T cell competence is a significant clinical challenge in patients whose thymic function is severely compromised due to age or cytoreductive conditioning. Here, we demonstrate in mice that mesenteric LNs (MLNs) support extrathymic T cell development in euthymic and athymic recipients of bone marrow transplantation (BMT). Furthermore, in aged murine BMT recipients, the contribution of the MLNs to the generation of T cells was maintained, while the contribution of the thymus was significa ...[more]