Ontology highlight
ABSTRACT:
SUBMITTER: Chiabrando D
PROVIDER: S-EPMC3533534 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Chiabrando Deborah D Marro Samuele S Mercurio Sonia S Giorgi Carlotta C Petrillo Sara S Vinchi Francesca F Fiorito Veronica V Fagoonee Sharmila S Camporeale Annalisa A Turco Emilia E Merlo Giorgio R GR Silengo Lorenzo L Altruda Fiorella F Pinton Paolo P Tolosano Emanuela E
The Journal of clinical investigation 20121126 12
Feline leukemia virus subgroup C receptor 1 (FLVCR1) is a cell membrane heme exporter that maintains the balance between heme levels and globin synthesis in erythroid precursors. It was previously shown that Flvcr1-null mice died in utero due to a failure of erythropoiesis. Here, we identify Flvcr1b, a mitochondrial Flvcr1 isoform that promotes heme efflux into the cytoplasm. Flvcr1b overexpression promoted heme synthesis and in vitro erythroid differentiation, whereas silencing of Flvcr1b cause ...[more]