Ontology highlight
ABSTRACT:
SUBMITTER: Engeli S
PROVIDER: S-EPMC3533552 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Engeli Stefan S Birkenfeld Andreas L AL Badin Pierre-Marie PM Bourlier Virginie V Louche Katie K Viguerie Nathalie N Thalamas Claire C Montastier Emilie E Larrouy Dominique D Harant Isabelle I de Glisezinski Isabelle I Lieske Stefanie S Reinke Julia J Beckmann Bibiana B Langin Dominique D Jordan Jens J Moro Cedric C
The Journal of clinical investigation 20121101 12
Cardiac natriuretic peptides (NP) are major activators of human fat cell lipolysis and have recently been shown to control brown fat thermogenesis. Here, we investigated the physiological role of NP on the oxidative metabolism of human skeletal muscle. NP receptor type A (NPRA) gene expression was positively correlated to mRNA levels of PPARγ coactivator-1α (PGC1A) and several oxidative phosphorylation (OXPHOS) genes in human skeletal muscle. Further, the expression of NPRA, PGC1A, and OXPHOS ge ...[more]