Ontology highlight
ABSTRACT:
SUBMITTER: Pasula S
PROVIDER: S-EPMC3533553 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Pasula Satish S Cai Xiaofeng X Dong Yunzhou Y Messa Mirko M McManus John J Chang Baojun B Liu Xiaolei X Zhu Hua H Mansat Robert Silasi RS Yoon Seon-Joo SJ Hahn Scott S Keeling Jacob J Saunders Debra D Ko Genevieve G Knight John J Newton Gail G Luscinskas Francis F Sun Xiaohong X Towner Rheal R Lupu Florea F Xia Lijun L Cremona Ottavio O De Camilli Pietro P Min Wang W Chen Hong H
The Journal of clinical investigation 20121126 12
Epsins are a family of ubiquitin-binding, endocytic clathrin adaptors. Mice lacking both epsins 1 and 2 (Epn1/2) die at embryonic day 10 and exhibit an abnormal vascular phenotype. To examine the angiogenic role of endothelial epsins, we generated mice with constitutive or inducible deletion of Epn1/2 in vascular endothelium. These mice exhibited no abnormal phenotypes under normal conditions, suggesting that lack of endothelial epsins 1 and 2 did not affect normal blood vessels. In tumors, howe ...[more]