Ontology highlight
ABSTRACT:
SUBMITTER: Seisenberger S
PROVIDER: S-EPMC3533687 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Molecular cell 20121206 6
Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells (PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are largely unknown. We have carried out whole-genome bisulfite sequencing (BS-Seq) and RNA-Seq across key stages from E6.5 epiblast to E16.5 PGCs. Global loss of methylation takes place during PGC expansion and migration with evidence for passive demethylation, but sequences that carry long-term epigenetic memory (imprints, CpG isla ...[more]