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Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency.

ABSTRACT: Useful diversity: Quantification of modified tRNA nucleobases in different murine and porcine tissues reveals a tissue-specific overall modification content. The modification content correlates with rates of protein synthesis in?vitro, suggesting a direct link between tRNA modification levels and tissue-specific translational efficiency.

SUBMITTER: Brandmayr C

PROVIDER: S-EPMC3533783 | biostudies-literature |

REPOSITORIES: biostudies-literature

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