Ontology highlight
ABSTRACT:
SUBMITTER: Morgan RM
PROVIDER: S-EPMC3534021 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Morgan Rhodri M L RM Hernández-Ramírez Laura C LC Trivellin Giampaolo G Zhou Lihong L Roe S Mark SM Korbonits Márta M Prodromou Chrisostomos C
PloS one 20121231 12
Mutations of the aryl hydrocarbon receptor interacting protein (AIP) have been associated with familial isolated pituitary adenomas predisposing to young-onset acromegaly and gigantism. The precise tumorigenic mechanism is not well understood as AIP interacts with a large number of independent proteins as well as three chaperone systems, HSP90, HSP70 and TOMM20. We have determined the structure of the TPR domain of AIP at high resolution, which has allowed a detailed analysis of how disease-asso ...[more]