Ontology highlight
ABSTRACT:
SUBMITTER: Zhou F
PROVIDER: S-EPMC3534639 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Zhou Feng F Xue Min M Qin Di D Zhu Xiaofei X Wang Cong C Zhu Jianzhong J Hao Tingting T Cheng Lin L Chen Xiuying X Bai Zhiqiang Z Feng Ninghan N Gao Shou-Jiang SJ Lu Chun C
PloS one 20130102 1
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is etiologically associated with KS, the most common AIDS-related malignancy. KS is characterized by vast angiogenesis and hyperproliferative spindle cells. We have previously reported that HIV-1 Tat can trigger KSHV reactivation and accelerate Kaposin A-induced tumorigenesis. Here, we explored Tat promotion of KSHV vIL-6-induced angiogenesis and tumorigenesis. Tat promotes vIL-6-induced cell proliferation, cellular transformation, vascular tub ...[more]