Ontology highlight
ABSTRACT: Objectives
We aimed at extending the Natural and Orthogonal Interaction (NOIA) framework, developed for modeling gene-gene interactions in the analysis of quantitative traits, to allow for reduced genetic models, dichotomous traits, and gene-environment interactions. We evaluate the performance of the NOIA statistical models using simulated data and lung cancer data.Methods
The NOIA statistical models are developed for additive, dominant, and recessive genetic models as well as for a binary environmental exposure. Using the Kronecker product rule, a NOIA statistical model is built to model gene-environment interactions. By treating the genotypic values as the logarithm of odds, the NOIA statistical models are extended to the analysis of case-control data.Results
Our simulations showed that power for testing associations while allowing for interaction using the NOIA statistical model is much higher than using functional models for most of the scenarios we simulated. When applied to lung cancer data, much smaller p values were obtained using the NOIA statistical model for either the main effects or the SNP-smoking interactions for some of the SNPs tested.Conclusion
The NOIA statistical models are usually more powerful than the functional models in detecting main effects and interaction effects for both quantitative traits and binary traits.
SUBMITTER: Ma J
PROVIDER: S-EPMC3534768 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Ma Jianzhong J Xiao Feifei F Xiong Momiao M Andrew Angeline S AS Brenner Hermann H Duell Eric J EJ Haugen Aage A Hoggart Clive C Hung Rayjean J RJ Lazarus Philip P Liu Changlu C Matsuo Keitaro K Mayordomo Jose Ignacio JI Schwartz Ann G AG Staratschek-Jox Andrea A Wichmann Erich E Yang Ping P Amos Christopher I CI
Human heredity 20120809 4
<h4>Objectives</h4>We aimed at extending the Natural and Orthogonal Interaction (NOIA) framework, developed for modeling gene-gene interactions in the analysis of quantitative traits, to allow for reduced genetic models, dichotomous traits, and gene-environment interactions. We evaluate the performance of the NOIA statistical models using simulated data and lung cancer data.<h4>Methods</h4>The NOIA statistical models are developed for additive, dominant, and recessive genetic models as well as f ...[more]