Ontology highlight
ABSTRACT:
SUBMITTER: Bailey CM
PROVIDER: S-EPMC3534779 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Bailey Caleb M CM Morrison Jason A JA Kulesa Paul M PM
Pigment cell & melanoma research 20120802 5
Cancer cells must regulate plasticity and invasion to survive and metastasize. However, the identification of targetable mechanisms to inhibit metastasis has been slow. Signaling programs that drive stem and progenitor cells during normal development offer an inroad to discover mechanisms common to metastasis. Using a chick embryo transplant model, we have compared molecular signaling programs of melanoma and their embryonic progenitors, the neural crest. We report that malignant melanoma cells ...[more]