Ontology highlight
ABSTRACT:
SUBMITTER: Cotto-Rios XM
PROVIDER: S-EPMC3534866 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Cotto-Rios Xiomaris M XM Békés Miklós M Chapman Jessica J Ueberheide Beatrix B Huang Tony T TT
Cell reports 20121206 6
Deubiquitinating enzymes (DUBs) constitute a large family of cysteine proteases that have a broad impact on numerous biological and pathological processes, including the regulation of genomic stability. DUBs are often assembled onto multiprotein complexes to assist in their localization and substrate selection, yet it remains unclear how the enzymatic activity of DUBs is modulated by intracellular signals. Herein, we show that bursts of reactive oxygen species (ROS) reversibly inactivate DUBs th ...[more]