Ontology highlight
ABSTRACT:
SUBMITTER: Bohnsack BL
PROVIDER: S-EPMC3534885 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Bohnsack Brenda L BL Kahana Alon A
Developmental biology 20121117 2
Craniofacial and ocular morphogenesis require proper regulation of cranial neural crest migration, proliferation, survival and differentiation. Although alterations in maternal thyroid hormone (TH) are associated with congenital craniofacial anomalies, the role of TH on the neural crest has not been previously described. Using zebrafish, we demonstrate that pharmacologic and genetic alterations in TH signaling disrupt cranial neural crest migration, proliferation, and survival, leading to cranio ...[more]