Ontology highlight
ABSTRACT:
SUBMITTER: Messner S
PROVIDER: S-EPMC3535351 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Archives of toxicology 20121111 1
Current 2-dimensional hepatic model systems often fail to predict chemically induced hepatotoxicity due to the loss of a hepatocyte-specific phenotype in culture. For more predictive in vitro models, hepatocytes have to be maintained in a 3-dimensional environment that allows for polarization and cell-cell contacts. Preferably, the model will reflect an in vivo-like multi-cell type environment necessary for liver-like responses. Here, we report the characterization of a multi-cell type microtiss ...[more]