Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype.

ABSTRACT:

Background

The rs3818361 single nucleotide polymorphism in complement component (3b/4b) receptor-1 (CR1) is associated with increased risk of Alzheimer's disease (AD). Although this novel variant is associated with a small effect size and is unlikely to be useful as a predictor of AD risk, it might provide insights into AD pathogenesis. We examined the association between rs3818361 and brain amyloid deposition in nondemented older individuals.

Methods

We used (11)C-Pittsburgh Compound-B positron emission tomography to quantify brain amyloid burden in 57 nondemented older individuals (mean age 78.5 years) in the neuroimaging substudy of the Baltimore Longitudinal Study of Aging. In a replication study, we analyzed (11)C-Pittsburgh Compound-B positron emission tomography data

SUBMITTER: Thambisetty M 

PROVIDER: S-EPMC3535537 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature