Ontology highlight
ABSTRACT:
SUBMITTER: Kalyva A
PROVIDER: S-EPMC3535570 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Kalyva Athanasia A Schmidtmann Anja A Geeves Michael A MA
Biochemistry 20120803 32
Tropomyosin (Tm) is a dimer made of two alpha helical chains associated into a parallel coiled-coil. In mammalian skeletal and cardiac muscle, the Tm is expressed from two separate genes to give the α- and β-Tm isoforms. These associate in vivo to form homo- (α(2)) and heterodimers (α·β) with little β(2) normally observed. The proportion of α(2) vs α·β varies across species and across muscle types from almost 100% α(2)- to 50% α·β-Tm. The ratio can also vary during development and in disease. Th ...[more]